Scenes of the Virgin; The Trinity; The Crucifixion

In the Trinity (top right), the four creatures with the heads of an eagle, man, ox and lion symbolise, respectively, the four Evangelists: John, Matthew, Luke and Mark. The 'Crucifixion' contains many of the incidents found in the nearly contemporary version of the same subject by Jacopo di Cione.

The donors, probably Juana Manuel (1335 - 1381), and her father Don Juan Manuel, are presented to the Virgin and Child by Saint Raphael. The artist painted two large altarpieces which were then sent to the Manuel Chapel in Murcia Cathedral in Spain. Now framed as a single panel, this may originally have formed two wings of a diptych.