Baldovinetti came from a wealthy Florentine family. As well as painting on panel and in fresco, he worked in stained glass and mosaic.
His style is marked by the influence of Domenico Veneziano, who was active in Florence from 1439 to 1445. As a painter Baldovinetti also shows an affinity with Piero della Francesca, who was also a pupil of Domenico Veneziano at that time.
Baldovinetti joined the painters' guild, the Compagnia di San Luca of Florence, in 1448 or 1449. His work was also influenced by Fra Angelico and Andrea del Castagno.
His fresco of the Nativity in the cloister of the church of Santissima Annunziata in Florence is the best known of his four surviving paintings.