It has been proposed that the foreground figures shown in this picture are Saint Roch and his attendant Gothardus, who tended the ulcer on Saint Roch's thigh.
If this is the case, the picture may have been painted to commemorate relief from the plague, against which Saint Roch was invoked in the Veneto in 1504.
At the extreme right Saint Anthony peers from his cave. In the right middle ground Saint George is shown on a rearing horse attacking a dragon. This part of the painting is, however, almost entirely the work of a mid-20th-century restorer.