The painting, an early work by Garofalo, probably dates from about 1499–1502. Saint Dominic is identified by the lily and the miraculous star on his chest. Saint Catherine's hands, feet and side are marked with Christ's wounds, known as the stigmata. The tethered monkey may represent man's base nature disciplined by the Christian faith. Christ's sacrifice is symbolised by the goldfinch which he holds on a string.