
This painting forms part of the predella, or base of the Santa Trinità Altarpiece. The scene here shows Jerome and the Lion. Other scenes from the predella include: Mamas in Prison thrown to the Lions; the Beheading of James the Great; and Zeno exorcising the daughter of the Emperor Gallienus. The predella was probably painted by Lippi and his workshop in Prato, between 1458 and 1460.
A fifth predella panel showing the vision of Saint Augustine while pondering the mystery of the Trinity has recently been identified as belonging to the altarpiece in the Hermitage, St Petersburg.